A lot of scientific epistemology or historiography focus on the methodology of discovery, the paradigm shifts of humans and the viability and/or rationality for accepting such shifts - and the varying conclusions as the whether or not we were correct to accept these (and what proof we should demand
in the future for the acceptance of scientific 'theories').
All of this can be reduced back to the impact of "myth" on our understanding of the world - the majority of the populace believes what they're told.
If we're told that apples fall because God commanded it; if we're told that it's because of some 'force'(gravitational) - none of this materially changes what we've experienced or what our experiences have conditioned us to expect - apples fall to the ground. All that scientific discourse has done, at least in the mundane sense, is rob us of our ability to appreciate experiences as unique and 'mystical'and given them, instead, the cold skepticism of Rationality.
Thus we are all skeptics. But to what end?